St. Vincent and the Grenadines maintains close ties to the U.S., Canada, and the U.K., and cooperates with regional political and economic organizations such as the Organization of Eastern Caribbean States (OECS) and CARICOM. St. Vincent and the Grenadines is a member of the United Nations, the Commonwealth of Nations, the Organization of American States, and the Association of Caribbean States (ACS).

As a member of CARICOM, St. Vincent and the Grenadines strongly backed efforts by the United States to implement UN Security Council Resolution 940, designed to facilitate the departure of Haiti's de facto authorities from power. The country agreed to contribute personnel to the multinational force, which restored the democratically elected government of Haiti in October 1994.

St. Vincent and the Grenadines maintains close relations with Cuba, which provides a number of scholarship and other exchange programs for Vincentians, particularly in the field of health care.