Guinea-Bissau follows a nonaligned foreign policy and seeks friendly and cooperative relations with a wide variety of states and organizations. France, Portugal, Brazil, Egypt, Nigeria, Taiwan, Libya, Cuba, Sweden, the Palestine Liberation Organization, and Russia have diplomatic offices in Bissau.

Guinea-Bissau is a member of the UN and many of its specialized and related agencies, including the World Bank and the International Monetary Fund (IMF); African Development Bank (AFDB), Economic Community of West African States (ECOWAS), West African Economic and Monetary Union (WAEMU), Organization of the Islamic Conference (OIC), Organization of African Unity (OAU), and permanent Interstate Committee for drought control in the Sahel (CILSS). Guinea-Bissau also is a member of the G-77, ICAO, FAO and WHO.