Eritrea is a member of the African Union (AU, successor organization to the Organization of African Unity) and of the Common Market of Eastern and Southern Africa (COMESA). It has had close relations with the United States, Italy, and several other European nations, including the United Kingdom, Germany, Norway, and the Netherlands, which have become important aid donors. Relations with these countries became strained as a result of the 2001 government crackdown against political dissidents and others, the closure of the independent press, and by the expulsion of the Italian Ambassador to Eritrea. Efforts have been made to repair relations with donor countries.

Eritrea's relations with its neighbors other than Djibouti also are somewhat strained. Although a territorial dispute with Yemen over the Haynish Islands was settled by international arbitration, tensions over traditional fishing rights with Yemen resurfaced in 2002. Relations with Sudan also were colored by occasional incidents involving the extremist group, Eritrean Islamic Jihad (EIJ)--which the Eritrean Government believes is supported by the National Islamic Front government in Khartoum--and by continued Eritrean support for the Sudanese opposition coalition, the National Democratic Alliance.