In April 1977, the United States established a Consulate General in Djibouti and at independence several months later raised its status to an embassy. The first U.S. Ambassador to the Republic of Djibouti arrived in October 1980. The United States provides about $7 million in primarily humanitarian assistance which is distributed multilaterally.

Djibouti has allowed the U.S. military, as well as other nations, access to its port and airport facilities. The Djiboutian Government has generally been supportive of U.S. and Western interests, as was demonstrated during the Gulf crisis of 1990-91. After the tragic events of September 11, 2001, Djibouti quickly supported international efforts to fight terrorism. As a victim of past international terrorist attacks, President Ismail Omar Guelleh took a very proactive position among Arab League members to support coalition efforts.

The U.S. Embassy in Djibouti is located at Villa Plateau du Serpent, Blvd. Marechal Joffre (Boite Postal 185), Djibouti (tel. 253 35-39-95; fax 253 35-39-40).