There are more than 80 ethnic groups in the C.A.R., each with its own language. About 75% are Baya-Mandjia and Banda (40% largely located in the northern and central parts of the country), and 4% are M'Baka (southwestern corner of the CAR. Sangho, the language of a small group along the Oubangui River, is the national language spoken by the majority of Central Africans. Only a small part of the population has more than an elemental knowledge of French, the official language.

More than 55% of the population of the C.A.R. lives in rural areas. The chief agricultural areas are around the Bossangoa and Bambari. Bangui, Berberati, Bangassou, and Bossangoa are the most densely populated urban centers.