In 1969, Colombia, along with Bolivia, Chile, Ecuador and Peru, formed what is now the Andean Community. (Venezuela joined in 1973 and Chile left in 1976.) In the 1980s, Colombia broadened its bilateral and multilateral relations, joining the Contadora Group, the Group of Eight (now the Rio Group), and the Non-Aligned Movement, which it chaired from 1994 until September 1998. In addition, it has signed free trade agreements with Chile, Mexico, and Venezuela.

Colombia has traditionally played an active role in the United Nations and the Organization of American States and in their subsidiary agencies. Former President Gaviria became Secretary General of the OAS in September 1994 and was re-elected in 1999. Colombia was a participant in the December 1994 and April 1998 Summits of the Americas and followed up on initiatives developed at the summit by hosting two post-summit, ministerial-level meetings on trade and science and technology.