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Generic Name: E: GLYBURIDE (GLYE-byoo-ride) and METFORMIN (met-FOR-min) Common Uses of Glucovance This anti-diabetic medicine is a combination of two medicines (a sulfonylurea and a biguanide). It is used along with a diet and exercise program to control high blood sugar in patients with type 2 diabetes (non-insulin-dependent diabetes). This medicine works by stimulating the release of your body's natural insulin and by restoring your body's proper response to insulin. Controlling high blood sugar helps prevent heart disease, strokes, kidney disease, blindness, and circulation problems, as well as sexual function problems (impotence). Possible Glucovance Side Effects Side effects, that may occur initially during treatment, include nausea, stomach upset, diarrhea, or weight gain. If they continue or are bothersome, check with your doctor. Contact your doctor immediately if your stomach symptoms recur later (after you are taking the same dose for several days or weeks). A later recurrence of stomach symptoms may be due to lactic acidosis. Contact your doctor immediately if you experience persistent sore throat or fever, easy bleeding or bruising, severe stomach pain, yellowing eyes or skin, dark urine, unusual tiredness or weakness, unusual or sudden weight gain, mental/mood changes, swelling of the hands or feet, or seizures. This medicine can cause low blood sugar (hypoglycemia). This effect may occur if you do not consume enough calories (from food, juices, fruit, etc). The symptoms include chills, cold sweat, blurred vision, dizziness, drowsiness, shaking, rapid heartbeat, weakness, headache, fainting, tingling of the hands or feet, or hunger. It is a good habit to carry glucose tablets or gel to treat low blood sugar. If you are in a situation where you don't have these reliable forms of glucose, eat a quick source of sugar such as table sugar, honey, or candy, or drink a glass of orange juice or non-diet soda to quickly raise your blood sugar level. Tell your doctor immediately about the reaction. To help prevent hypoglycemia, eat meals on a regular schedule and do not skip meals. Symptoms of high blood sugar (hyperglycemia) include thirst, increased urination, confusion, drowsiness, flushing, rapid breathing, or fruity breath odor. If these symptoms occur, tell your doctor immediately. Your medicine dosage may need to be increased. An allergic reaction to this medicine is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include rash, itching, swelling, dizziness, or trouble breathing. If you notice other effects not listed above, contact your doctor, nurse, or pharmacist. General CautionsKeep all doctor and laboratory appointments while you are using this medicine. Laboratory and/or medical tests (e.g., liver and kidney function tests, fasting blood glucose, glycosylated hemoglobin, complete blood counts) should be performed periodically to monitor your progress or check for side effects. Regularly check your blood or urine for sugar, as directed by your doctor or pharmacist. You may experience blurred vision, dizziness, or drowsiness due to extremely low or high blood sugar levels; use caution engaging in activities requiring alertness such as driving or using machinery. Limit alcohol intake while using this medicine because it can increase the risk of developing hypoglycemia. Rarely, alcohol can interact with glyburide and cause a serious reaction (disulfiram-like reaction) with symptoms such as facial flushing, nausea, vomiting, dizziness, or stomach pain. Consult your doctor or pharmacist about the safe use of alcohol. During times of stress, such as fever, infection, injury, or surgery, it may be more difficult to control your blood sugar. Consult your doctor, as a change in your medicine may be required. This medicine may cause increased sensitivity to the sun. Avoid exposure to the sun or sunlamps until you know how you react to this medicine. Use a sunscreen or protective clothing if you must be outside for a prolonged period. If you are scheduled to undergo any x-ray or scanning procedure using injectable iodinated contrast material, be sure to inform your doctor that you are taking this medicine. You will need to temporarily stop this medicine around the time of your procedure. Consult your doctor for further instructions. Before you begin taking any new medicine, either prescription or over-the-counter, check with your doctor or pharmacist. Caution is advised when using this medicine in the elderly because they may be more sensitive to the effects of this medicine. For Women: this medicine can cause changes in the menstrual cycle (promote ovulation) in women with certain fertility problems, increasing the risk of becoming pregnant. Consult your doctor or pharmacist about the use of reliable birth control while using this medicine. If you plan on becoming pregnant, discuss with your doctor the benefits and risks of using this medicine during pregnancy. Use of this medicine is not recommended for at least 2 weeks prior to delivery due to the potential for fetal harm. Insulin may be preferred during pregnancy. Discuss all options with your doctor. It is unknown if this medicine is excreted in breast milk. Do not breast-feed while taking this medicine.
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