Design improvements in newer trucks reduce stress and increase the efficiency of long-distance drivers. Many of the newer trucks are virtual mini-apartments on wheels, equipped with refrigerators, televisions, and bunks.

The U.S. Department of Transportation governs work hours and other working conditions of truck drivers engaged in interstate commerce. A long-distance driver cannot work more than 60 hours in any 7-day period. Federal regulations also require that truckers rest 10 hours for every 11 hours of driving. Many drivers, particularly on long runs, work close to the maximum time permitted because they typically are compensated according to the number of miles or hours they drive. Drivers on long runs may face boredom, loneliness, and fatigue. Drivers frequently travel at night, and on holidays and weekends, to avoid traffic delays and deliver cargo on time.

Local truck drivers frequently work 50 or more hours a week. Drivers who handle food for chain grocery stores, produce markets, or bakeries typically work long hours, starting late at night or early in the morning. Although most drivers have regular routes, some have different routes each day. Many local truck drivers, particularly driver/sales workers, load and unload their own trucks. This requires considerable lifting, carrying, and walking each day.