According to the American Physical Therapy Association, there were 245 accredited physical therapist assistant programs in the United States as of 2003. Accredited physical therapist assistant programs are designed to last 2 years, or 4 semesters, and culminate in an associate degree. Programs are divided into academic study and hands-on clinical experience. Academic course work includes algebra, anatomy and physiology, biology, chemistry, and psychology. Many programs require that students complete a semester of anatomy and physiology and have certifications in CPR and other first aid even before they begin their clinical field experience. Both educators and prospective employers view clinical experience as integral to ensuring that students understand the responsibilities of a physical therapist assistant.

Employers typically require physical therapist aides to have a high school diploma, strong interpersonal skills, and a desire to assist people in need. Most employers provide clinical on-the-job training.