Commercial pilots also may have irregular schedules, flying 30 hours one month and 90 hours the next. Because these pilots frequently have many nonflying responsibilities, they have much less free time than do airline pilots. Except for business pilots, most do not remain away from home overnight. They may work odd hours. Flight instructors may have irregular and seasonal work schedules, depending on their students' available time and the weather. Instructors frequently work in the evening or on weekends.

Airline pilots, especially those on international routes, often suffer jet lag—fatigue caused by many hours of flying through different time zones. To guard against excessive pilot fatigue that could result in unsafe flying conditions, the FAA requires airlines to allow pilots at least 8 hours of uninterrupted rest in the 24 hours before finishing their flight duty. The work of test pilots, who check the flight performance of new and experimental planes, may be dangerous. Pilots who are crop dusters may be exposed to toxic chemicals and seldom have the benefit of a regular landing strip. Helicopter pilots involved in rescue and police work may be subject to personal injury.

Although flying does not involve much physical effort, the mental stress of being responsible for a safe flight, regardless of the weather, can be tiring. Pilots must be alert and quick to react if something goes wrong, particularly during takeoff and landing.