Factories are generally clean, well lit, and well ventilated, but sewing areas may be noisy. Operators often sit for long periods and lean over machines. New ergonomically designed chairs and machines that allow workers to stand during operation are some of the means that firms use to minimize discomfort for production workers. Another concern for workers is injuries caused by repetitive motions. The implementation of modular units and specially designed equipment reduces potential health problems by lessening the stress of repetitive motions. In 2002, cases of work-related injury and illness in the apparel industry averaged 4.6 per 100 workers, lower than the 7.2 average in all manufacturing industries, and about the same as the rate for all industries.

The movement away from traditional piecework systems often results in a significant change in working conditions. Modular manufacturing involves teamwork, increased responsibility, and greater interaction among coworkers than do traditional assembly lines.

Travel is an important part of the job for many managers and designers, who oversee the design and production of the apparel. As more production moves abroad, foreign travel is becoming more common.